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Effect of diets with Cucurbita moschata, Jobˈs tears and Cudrania tricuspidata powder supplement on body fat, fecal amount, intestinal length and serum lipid contents in rats fed a high fat diet
Author(s) -
Han Chan-Kyu,
Park Ju-Hun,
Cho Kyung-Dong,
Lee Kyoung-Won,
Sung Ki-Seung,
Lee Bog-Hieu
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb428
Subject(s) - cucurbita moschata , feces , adipose tissue , chemistry , cholesterol , zoology , food science , medicine , endocrinology , biology , paleontology , alternative medicine , pathology
This study was performed to investigate the effects of mixed‐diet with three functional food ingredients ( Cucurbita moschata Duch.: CM, Jobˈs tears: JT, Cudrania tricuspidata : CT) on body fat, fecal amount, intestinal length and serum lipid contents in rats fed a high fat diet. Male SD rats were fed a high‐fat diet ( D12492 , 45 kcal fat) for 5 weeks during the first phase. In the second phase, which lasted 5 weeks, the rats were fed a high‐fat diet only (A, control), high‐fat diet with 10% mixed‐powder in the same ratio CM, JT and CT (B), and its mixed‐powder 20% (C), and 30% (D), respectively. Body weight gain and FER was lower in the group B, C, and D than in group A, but was not significantly different among the groups. The organ weights were similar in the experimental groups, and adipose tissue weights in groups with CM, JT, CT mixed‐powder were significantly lower than in the group A (p<0.05). The fecal weights of groups C and D increased significantly during the second phase compared to the group A (p<0.05), and the length of large intestine was significantly longer in the group C than in group A (p<0.05). The serum total cholesterol, LDL‐cholesterol and glucose contents were significantly decreased in the diet groups with mixed‐powder supplement than in the group A (p<0.05). These results indicate that supplementation with CM, JT, and CT seemed to be effective in decreasing body fat, blood lipid and glucose levels, and also in increasing fecal amount in rats fed a high‐fat diet.