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Mathematical modeling of one‐carbon metabolism in trisomy 21
Author(s) -
Chango Abalo,
Gnimpieba Etienne Z.,
Eveillard Damien
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb420
Subject(s) - cystathionine beta synthase , in silico , metabolism , trisomy , gene , atp synthase , chemistry , biology , biochemistry , computational biology , genetics , enzyme , cysteine
Cystathionine b‐synthase gene is overexpressed in Down syndrome. We have successfully used a mathematical model to study the impact of CBS overexpression on the one‐carbon metabolism. (150% of its normal Vmax) changed the profile of metabolites when compared with 100% of Vmax. The model allowed running the overexpression of RFC, FTCD and GART. The model may be a helpful tool in the future to study in silico metabolic and disease processes.