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Effect of Oral Administration of Water Soluble Extract from Citrus Peel (Citrus unshiu) on Suppressing Alcohol Induced Fatty Liver in Rats
Author(s) -
Park Yongkon,
Choi Inwook,
Park Ho-young
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb385
Subject(s) - citrus unshiu , chemistry , ethanol , oleic acid , fatty liver , alcohol , oral administration , triglyceride , dose , food science , pharmacology , medicine , biochemistry , cholesterol , botany , biology , disease
Water soluble citrus peel extract (WCE) from Citrus unshiu was investigated on its anti‐alcoholic fatty liver activities through chronic oral administration to Sprague Dawley (SD) rats. WCE, which was prepared by ultrasound‐assisted extraction (UAE), was co‐supplemented with ethanol (2.87 ml/rat/day) at low and high dosages (278 and 576 mg/rat/day, respectively) for 6 weeks. Ethanol consumption significantly elevated both total cholesterol (TC) and triglyceride (TG) concentrations in the serum of SD rats otherwise co‐administration of WCE lowered both serum TG and TC levels. Ethanol consumption caused hepatic lipid content of 227.0 mg/g liver after 6 weeks whereas co‐administration of WCE, especially at high dosage, significantly reduced it to 186.9 mg/g liver. Analysis of hepatic fatty acids revealed that WCE suppressed conjugation of oleic acid into TG. These results support probable application of WCE as an anti‐alcoholic fatty liver agent.