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Oral administration of dead Lactobacillus sakei inhibits atopic dermatitis‐like skin lesion in NC/Nga mice
Author(s) -
KIM JI YUN,
Pyo Suhkneung
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb364
Subject(s) - lactobacillus sakei , atopic dermatitis , immunoglobulin e , in vivo , allergy , medicine , histamine , immune system , immunology , scratching , lesion , in vitro , pharmacology , chemistry , biology , lactobacillus , pathology , antibody , food science , biochemistry , physics , microbiology and biotechnology , acoustics , fermentation
Atopic dermatitis (AD) is a chronic inflammatory skin disease which is characterized by pruritic skin lesions. Probiotics such as lactobacilli and bifidobacteria have been known to generate beneficial biological effects including modulation of immune responses and have been suggested as new effective anti‐inflammatory agents. However, the effect of heat‐killed L. sakei proBio65 isolated from Kimchi has not been elucidated. This study was undertaken to investigate the inhibitory effect of dead L. sakei proBio65 on allergic responses in vivo and in vitro. In NC/Nga mouse model, our result revealed that oral administration of heat‐killed L. sakei proBio65 improved skin condition and reduced scratching frequency. In addition, ELISA assay showed that the treatment with dead L. sakei proBio65 resulted in the inhibition of serum IgE and IL‐4 production. The present data also demonstrated that dead L. sakei proBio65 inhibited IgE‐mediated histamine and β‐hexosaminidase release from RBL‐2H3 cells. Taken together, these results suggest that dead L. sakei proBio65 has an inhibitory effect on atopic dermatitis (AD)‐like skin lesion and is proposed as a potential treatment for allergies.