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Parity and Pre‐pregnancy Obesity are Independently Associated with Delayed Lactogenesis in Women with History of Gestational Diabetes: Preliminary Results from the SWIFT Study
Author(s) -
Matias Susana Lilian,
Chiang Vicky,
Dewey Kathryn G,
Gunderson Erica P
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb348
Subject(s) - medicine , gestational diabetes , obstetrics , pregnancy , gynecology , population , parity (physics) , obesity , incidence (geometry) , gestation , endocrinology , environmental health , optics , genetics , physics , particle physics , biology
We used baseline data (n=1014) from SWIFT, a prospective study of women with gestational diabetes mellitus (GDM) within Kaiser Permanente (KP) in California, to determine the incidence of delayed lactogenesis and its association with selected maternal prenatal and delivery characteristics. Onset of lactogenesis II was assessed at baseline (6–9 weeks postpartum) by maternal report as well as pre‐pregnancy and pre‐delivery weights, and height was measured. Delayed lactogenesis was defined as onset of lactogenesis II occurring after 72 hours postpartum. Results from a prenatal 3‐hour 100 g oral glucose tolerance test (OGTT) were obtained from KP electronic records. Severity of GDM was measured by number of abnormal OGTT plasma values. Delayed lactogenesis occurred in 33% of postpartum nondiabetic women. After adjusting for maternal, labor and delivery characteristics, primiparity and pre‐pregnancy obesity were independently associated with delayed lactogenesis in this population. High priority for early postpartum lactation support should be given to GDM women who are obese before pregnancy and primiparous. This study was funded by the National Institute of Child Health and Human Development (NICHD), R01 HD050625, R01 HD050625‐03S1, and R01 HD050625‐05S. This project was also partially supported by the National Institutes of Health National Center for Research Resources UCSF‐CTSI UL1 RR024131.