Premium
Chronic oral administration of Lactobacillus casei rhamnosus 35 can modulate the gut microflora in rats
Author(s) -
Lin Yu-Chuan,
Tsai Jyun-Han,
Tsao Shu-Ping,
Huang Hui-Yu
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb291
Subject(s) - lactobacillus casei , lactobacillus rhamnosus , cecum , probiotic , gut flora , feces , microbiology and biotechnology , biology , food science , lactobacillus , bacteria , immunology , ecology , genetics , fermentation
Previous studies demonstrated that oral consumption of micro‐organisms can protect the gut flora. The objective of this study was to investigate the Lactobacillus casei rhamnosus 35 whether has probiotics potential on gastro intestinal (GI) protective effect in rats. Sprague Dawley rats (n=32) were divided into four groups, such as control (Con), low dose (LD), medium dose (MD) and high dose (HD). L. casei rhamnosus 35 was orally given for 8‐ week to the experimental rats. Changes in whole bodyweights and daily food intake were monitored throughout the study, and found no significant different among the groups. For the gut microflora analysis, viable cell counts of Lactobacilli, Bifidobacteria, total anaerobic bacteria counts, Escherichia coli, and Clostridium perfringens were determined from the feces and cecum of rats. In the results we found that L. casei rhamnosus 35 treatment significantly enhanced the beneficial effects on gut microflora, but suppressed the bacterial pathogens in the feces and cecum. Findings from our study suggest that L. casei rhamnosus 35 is a potential source of probiotic in rats.