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Semi‐quantitative analysis of milk proteomes reveals new evolving activities in carbohydrate metabolism in breastfeeding women
Author(s) -
Gao Xinliu,
Zhang Qiang,
McMahon Robert J,
Woo Jessica G,
Davidson Barbara S,
Morrow Ardythe L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb287
Subject(s) - colostrum , breastfeeding , lactose , carbohydrate metabolism , carbohydrate , proteome , biology , metabolism , proteomics , breast milk , biochemistry , food science , gene , medicine , genetics , antibody , pathology
Human milk proteins are thought to support a number of fundamental biological processes in the neonate. Among these processes may be carbohydrate metabolism, as lactose is abundant in the diet of the breastfed infant. Here we present semi‐quantitative analysis of whey proteins of human colostrum (first week, n = 3) and corresponding mature milk (3 mo.) by shotgun proteomics. Extended Gene Ontology of the identified proteins reveals that carbohydrate metabolism gene products are well represented in human milk. 80 proteins related to carbohydrate metabolism were identified, 24 of which were found to be significantly higher in mature milk. The diverse array of human milk proteins related to carbohydrate metabolism and their higher abundance in mature milk may suggest a role for human milk in adapting to increasing carbohydrate content during breastfeeding. The research is supported by Mead Johnson Nutrition and NIH HD 13021.