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Modulation Of Sympathetic Nervous, Renin Angiotensin And Kallikrein Kinin Systems On Youth Obesity
Author(s) -
Fernandes Fernanda Barrinha,
Fernandes Adriana Barrinha,
Febba Andreia Cristina Silva,
Leite Cleber Aparecido,
Souza Vitalle Maria Sylvia,
Arita Daniele Yuri,
Sousa Cunha Tatiana,
Jung Flavia Fernandes,
Casarini Dulce Elena
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb148
Subject(s) - endocrinology , medicine , bradykinin , renin–angiotensin system , chemistry , sympathetic nervous system , vasopressin , angiotensin ii , epinephrine , catecholamine , blood pressure , norepinephrine , obesity , receptor , dopamine
The aim of this study was to evaluate the relationship between obesity and Sympathetic Nervous (SNS), Renin Angiotensin (RAS) and Kallikrein Kinin (KKS) Systems. Subjects were divided in groups: 43 normal weight (NW), 14 overweight (OV), 37 obese (OB) and 10 MO (MO). The Ang I, Ang II, Ang‐(1–7), Bradykinin (BK), Vasopressin (VP), norepinephrine (NE), epinephrine (EP), serotonin (SE) plasmatic levels had been measured by HPLC. Ang (1–7) levels were lower in MO and OB compared with NW (0.06±0.04; 0.24±0.17 and 0.52±0.21nmol/mL). Ang I levels were higher in MO compared with NW (0.06±0.03; 0.03±0.02). OB had higher values of VP than NW (0.107±0.0217; 0.087±0.016ng/mL). OB had higher values of EP and NE than NW (48.3±20.3 vs 34.7±17.2 and 85.6±27.9 vs 45.9±28.3 pg/mL respectively). The NW had higher concentration of SE than the OV (281.2±113.0 vs 200.1±117.1 ng/mL). MO had lower BK levels than NW (0.367 vs 0.885). Our results showed a reduction of Ang (1–7) and increased of Ang I associated with weight gain in adolescents suggesting a modulation of ACE2 and NEP. According to our results, obesity in youth seems to be related with high levels of EP, NE, blood pressure and low Ang (1–7). These alterations in the SNS, RAS and KKS, associated with low levels of Ang 1–7 and BK may contribute to the development of hypertension in obese adolescents, since these can resulting in cardiovascular target organ damage such as the heart, the vascular wall and the kidney.