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Prospective Study To Investigate The Prevalence Of The 90 kDa Isoform Of Angiotensin Converting Enzyme In Vitória ‐ Brazil – Preliminary Results
Author(s) -
Febba Andreia Cristina Silva,
Barrinha Fernandes Fernan,
Aragão Danielle Sanches,
Franco Maria do Carmo,
Mill Jose Geraldo,
Castro Cintra Sesso Ricardo,
Casarini Dulce Elena
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.lb141
Subject(s) - prospective cohort study , urine , blood pressure , medicine , gene isoform , angiotensin converting enzyme , urinary system , endocrinology , population , cohort , renin–angiotensin system , enzyme , physiology , gastroenterology , chemistry , biochemistry , gene , environmental health
Essential hypertension is a multifactorial. We aimed to investigate the prevalence of the urinary 90 kDa N‐domain ACE in a cohort of the Brazilian population from Vitória, and to verify its association with essential hypertension. A prospective study was performed to verify the presence of the urinary 90 kDa N‐domain ACE, using the Western Blotting technique. The blood pressure was also measured. The groups were divided as 1(190/65kDa); 2(190/90/65kDa) and 3(90/65kDa) according to the presence of isoform. We separate the groups in relation to blood pressure, such as hypertensive and normotensive subjects. The urine were analyzed and compared to the first phase: We note that the first and second phase group 1 remained similar (3.3%); in the second phase the group 2 presented a decrease in the percentage of cases 33.3% vs 23.3% and the 3 group showed an increase in the percentage of cases in the second phase when compared to the first part of the study (63,3% vs 73,3%). There was an increase in cases of hypertensive subjetcs in the second part of the study from 50% to 63.3%. This analysis indicated more than 90% of subjects had 90kDa ACE in their urine;The second phase shows an increased number of subjects with isoforms of 90 and 65 kDa as well as increasing the number of hypertensive subjects; 3.3% were normotensive and not express the 90kDa isoform;These data suggest a relationship between hypertension and the presence of 90 kDa ACE.