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Decline in adipogenesis contributes to peripheral subcutaneous fat loss in older humans
Author(s) -
Caso Giuseppe,
McNurlan Margaret A,
Mileva Izolda,
Stein Seth,
Gelato Marie C
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.965.4
Subject(s) - adipogenesis , adipose tissue , endocrinology , medicine , proinflammatory cytokine , peripheral , inflammation , tumor necrosis factor alpha , insulin resistance , obesity
Aging is associated with redistribution of body fat characterized by a relative loss of subcutaneous limb fat and accumulation in trunk and visceral areas. The loss of subcutaneous peripheral fat is associated with metabolic abnormalities, particularly insulin resistance. The causes and mechanisms of loss of peripheral fat with aging are not completely clear. The aim of this study was to assess whether defects in adipogenesis contribute to fat loss in aging humans, as suggested from animal studies. Preadipocytes isolated from subcutaneous peripheral fat of healthy young and elderly subjects were compared in their ability to replicate and differentiate. The results show that both the rate of replication of subcutaneous peripheral preadipocytes and their ability to differentiate are impaired with aging. The reduction in adipogenesis is accompanied by a higher plasma level of the inflammatory marker, soluble tumor necrosis factor receptor 2, and greater release of tumor necrosis factor α from fat tissue. Thus, the gradual loss of peripheral fat in aging humans may in part result from a defect in adipogenesis, which may be linked to inflammation and/or to increased release of proinflammatory cytokines from fat tissue. (Supported by NIH grants DK049316 and 5‐MO1‐RR‐10710; and New York Empire Clinical Research Investigator Program (ECRIP) fellowships to GC and SS)