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Age‐dependent regulation of non‐coding RNAs in male germ cell development
Author(s) -
Luk Alfred CS,
Ng Shuk Han,
Chan Wai-Yee,
Lee Tin-Lap
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.922.17
Subject(s) - biology , germ cell , offspring , non coding rna , microrna , genetics , gene , developmental biology , pregnancy
Parental aging is a global problem that poses higher risk of genetics disorders for the offspring. While maternal aging has been exclusively studied, the effects of paternal aging remains largely elusive. Despite advances in functional genomics, majority of observations were taken from traditional genetics studies. Here we would like to examine the effect of paternal aging in male reproduction through studying the development of male germ cells. Rather than turning to known gene regulation, we identified non‐coding RNAs (ncRNAs) that demonstrate age‐dependent developmental regulation in male germ cell development by applying integrative analysis of our previous established GermSAGE and TileMapper resources. The findings strongly suggested the pivot role of ncRNAs in male germ cell development, and are expected to substantially change the concepts of ncRNA function in developmental, reproductive and stem cell biology.