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Caffeic Acid Phenethyl Ester protects burn wounds against oxidative stress and improves wound healing
Author(s) -
Monte-Alto-Costa Andrea,
Santos Jeanine Salles
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.916.8
Subject(s) - caffeic acid phenethyl ester , burn wound , burn injury , oxidative stress , medicine , wound healing , scalding , myeloperoxidase , catalase , chemistry , anesthesia , antioxidant , caffeic acid , surgery , biochemistry , food science , inflammation
Caffeic acid phenethyl ester (CAPE) is an active component of propolis, and has been shown to have anti‐inflammatory and antioxidant effects; in this study we studied its effects on burn wound healing. Twenty one female Wistar rats were divided in three groups: control (no burn)+CAPE, burn and burn+CAPE. A third‐degree burn was created. The CAPE treatment (10 μmol kg‐1; i.p.) began immediately after burn and lasted until euthanasia (14 days after burn). Fourteen days after wounding the burn+CAPE group presented greater wound contraction when compared to burn group. In plasma, lipid peroxidation was higher in burn group compared to control and burn+CAPE group. In wounds, burn+CAPE group presented a smaller lipid peroxidation than burn group. Carbonyl levels in plasma and lesions of the burn group were increased when compared to control group. In burn+CAPE group carbonyls levels were greater than the control only in wounds. Catalase activity was also analysed, and burn+CAPE group presented greater activity when compared to burn, but without difference when compared to the control group. It was also observed that both burn and burn+CAPE groups present a higher myeloperoxidase activity than control group, but the burn+CAPE group presented smaller myeloperoxidase activity compared to burn group. CAPE treatment improved wound contraction and reduced the oxidative damage of burns. Support: CAPES