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Mathematical modeling of wound healing using Compucell3D multicell modeling environment
Author(s) -
Gens John Scott,
Jeyaraman Srividhya,
Glazier James A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.916.10
Subject(s) - wound healing , extracellular matrix , mesenchymal stem cell , microbiology and biotechnology , cell , cell culture , cell growth , regeneration (biology) , chemistry , biomedical engineering , biology , immunology , medicine , biochemistry , genetics
Recent experimental studies suggest that contact inhibition (CI) of cell growth is a key mechanism during wound healing. Here we implement a 3D modeling method to explicitly model complex interactions of CI with local EGF concentrations during epithelial wound healing in cultured mammary epithelial cells. Model predictions are compared to patterns of cell growth observed in culture. Models presented are easy to modify and extensible to other epithelial cell types, to mesenchymal cells such as fibroblasts, and to epithelial cells grown on extracellular matrix or mesenchymal tissue. This publication was made possible by US EPA grant number R834289.