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Elucidating the Proteolytic Regulation of Bioactive Peptides
Author(s) -
Saghatelian Alan
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.91.2
Subject(s) - function (biology) , biochemistry , enzyme , biology , peptide , hormone , proteolytic enzymes , computational biology , neuropeptide , chemistry , microbiology and biotechnology , receptor
Peptide hormones and neuropeptides are an important class of physiological regulators that mediate a number of important processes, such as glucose metabolism, blood pressure and pain. Understanding the enzymatic regulation of peptides can reveal the biochemical function of enzymes and inform us how these peptides are regulated. Despite transformative advances in many areas of biological research we still lack a general approach assigning the enzymes that regulate specific bioactive peptides in vivo. We solve this problem by developing an integrated strategy that combines peptidomics, biochemistry and genetics to elucidate the peptidases that regulate physiological levels of bioactive peptides.