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Production of a biodegradable electrospun biomaterial with tensile strength and elasticity
Author(s) -
Wagner William D,
Argenta Louis C,
Morykwas Michael J,
Levi-Polyachenko Nicole
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.905.2
Subject(s) - biomaterial , ultimate tensile strength , materials science , composite material , glutaraldehyde , prepolymer , biomedical engineering , silk , young's modulus , biocompatibility , nanofiber , chemistry , polyurethane , nanotechnology , medicine , chromatography , metallurgy
Biodegradable biomaterials are essential to provide a temporary matrix for replacement or repair of tissues to resume function. The aim of the present study was 1) to develop a new biomaterial containing a blend of Collagen (80%) and poly (octanediol citrate), (POC) (20%), a soft material capable of providing an elastomeric cross‐linked polyester network and 2) to evaluate the physical, mechanical and functional properties of the biomaterial. Following chemical synthesis of POC, prepolymer was dissolved with type I Collagen and nanofibers were electrospun. Fibers within mats were thermally and chemically cross‐linked using heat and glutaraldehyde vapor respectively. Electrospun mats were hydrated in physiologic saline and physically were soft and elastic. Mechanical testing according to ASTM standards showed an elastic modulus of 0.46 ± 0.02 N/mm 2 (mean ± SEM) and an elongation at break of 16.4 ± 0.9mm (mean ± SEM). Using a radial pressure expansion and relaxation system relaxation of the material was observed for over 10 cycles. Based on findings of the study and low tissue inflammatory responses of POC and Collagen the material described is versatile in biomedical applications especially in those such as skin repair where repetitive deformation can occur during healing.