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Mathematical Modeling of Myeloma Bone Disease
Author(s) -
Ayati Bruce P
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.905.12
Subject(s) - multiple myeloma , stromal cell , bone disease , set (abstract data type) , bone remodeling , disease , cancer research , medicine , computer science , pathology , osteoporosis , programming language
We exhibit the role mathematics can play in the study of multiple myeloma and the attendant dysregulated bone remodeling. We discuss our approach to the “local” interactions of the microenvironment (osteoclasts, osteoblasts, and stromal cells) and the myeloma tumor cells. The local model is then embedded in a spatially explicit model, based on level‐set equations, to represent the system at larger spatial scales.