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The effects of 7 day exposure to intermittent hypoxia on renal and cervical sympathetic nerve responses to acute hypoxia in rats
Author(s) -
Eubank Wendy,
Yamamoto Kenta,
Franzke Michelle,
Mifflin Steve
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.899.11
Subject(s) - hypoxia (environmental) , medicine , intermittent hypoxia , stimulation , anesthesia , apnea , sympathetic activity , sympathetic nervous system , endocrinology , heart rate , obstructive sleep apnea , oxygen , blood pressure , chemistry , organic chemistry
Intermittent hypoxia (IH) is a widely used model for the repetitive bouts of hypoxia that occur during sleep apnea. Chronic IH enhances cervical sympathetic response to acute hypoxia. We sought to determine if the renal and cervical sympathetic nerve responsiveness to acute hypoxia was enhanced after 7 days exposure to IH. Adult, male Sprague‐Dawley rats (350–500grams) were exposed to IH (9% oxygen for 3min every 10 min, 8 h per day) for 7 days while control rats were maintained in normoxia. Renal and cervical discharge responses to acute hypoxia were determined by reducing fIO 2 by N 2 inhalation for 10, 15, 20 and 30 sec in anesthetized condition. 7 day IH did not alter the renal sympathetic response to acute hypoxia (n = 4) when compared to the control group (n = 10). Cervical sympathetic response to 20s and 30s hypoxia stimulation were lower in IH group (n = 4) than in control the group (n =10) (renal: 19.9 ± 8.1, 26.2 ± 13.4; vs cervical: 4.3 ± 2.8, 7.7 ± − 4.7, P < 0.05, mean ± S.E.M). These results suggest that 7 days exposure to IH attenuated the cervical sympathetic response to acute hypoxia while the renal sympathetic response was maintained. Supported by HL‐088052