Premium
Combined acute intermittent hypoxaemia and a high glucose/lipid load augments oxidative stress and exaggerates postprandial hyperglycaemia
Author(s) -
Griffin Harry Sebastian,
Pugh Keith,
Wadley Alex J,
Turner James E,
Aldred Sarah,
Taheri Shahrad,
Kumar Prem,
Balanos George M
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.898.3
Subject(s) - postprandial , medicine , endocrinology , hyperlipidemia , oxidative stress , lipid oxidation , diabetes mellitus , insulin , antioxidant , chemistry , biochemistry
In obstructive sleep apnea (OSA), intermittent hypoxemia (IH) induces oxidative stress (OxS), mediating an increased risk of cardiovascular disease. Hyperglycemia increases OxS during ischemic reperfusion injury, which shares a similar pattern of hypoxia and re‐oxygenation with IH. Postprandial hyperlipidemia alone, is also associated with increased OxS. Therefore, we hypothesized that OxS during IH would be increased by postprandial hyperglycemia and hyperlipidemia. 9 males undertook 3 trials. Trial 1: High glucose/lipid meal + 6h IH. Trial 2: High glucose/lipid meal + 6h room air. Trial 3: Low glucose/lipid meal + 6h IH. Blood samples were assessed for biomarkers of OxS, and glucose/lipid levels. Simultaneous, but not individual exposures to IH and high glucose/lipid ingestion increased plasma lipid peroxides (baseline 6.68 ± 0.66 vs. 6h 8.34 ± 0.58 nM/ml) accompanied by increased antioxidant capacity (baseline 417 ± 23.9 vs. 6h 477 ± 23.2 μM/ml). Despite consumption of identical meals, blood glucose levels at 1 and 1.5h were significantly higher during IH vs. room air (7.58 ± 0.59 vs. 6.52 ± 0.45 and 9.04 ± 0.57 vs. 7.25 ± 0.68 mM/L). Hyperglycemia and/or hyperlipidemia increase OxS during IH and it is associated with a compensatory increase in antioxidant capacity. IH also augmented postprandial hyperglycemia. These findings are relevant to all OSA patients and in particular those with coexisting diabetes.