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Participation of Locus coeruleus (LC) noradrenergic neurons on breathing in female rats
Author(s) -
Carvalho Debora,
Marques Danuzia A,
Szawka Raphael E,
Alselmo-Franci Janete,
Bicego Kenia C,
Gargaglioni Luciane H.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.894.9
Subject(s) - locus coeruleus , ovariectomized rat , endocrinology , medicine , hypercapnia , ventilation (architecture) , tidal volume , control of respiration , ascorbic acid , chemistry , respiratory system , hormone , anesthesia , central nervous system , mechanical engineering , food science , engineering
LC has been reported to regulate CO 2 ‐drive to breathing in males. Since, sex hormones have a significant impact on ventilation; the present study examined the role of LC noradrenergic neurons in estradiol‐treated ovariectomized (OVX+E2) rats in response to hypercapnia. To selectively destroy LC noradrenergic neurons we administered 6‐hydroxydopamine (6‐OHDA, 8 μg in 1 μL of vehicle) bilaterally or vehicle (ascorbic acid) into LC of OVX+E2 rats. Bilateral inhibition of LC neurons with 6‐OHDA reduced resting respiratory frequency (57±3.53, vs. vehicle: 93.5±3.75 breaths/min) and the increase in ventilation produced by hypercapnia (7% CO 2 ) (1052.5±11.5, vs. vehicle: 1625±89.7 mL/min/kg). Our results also suggest that noradrenergic LC neurons play an important modulation in the control of ventilation during resting or hypercapnic conditions in female rats. Financial support: FAPESP, CNPq and INCT of Comparative Physiology
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