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Gastric CO 2 output via the esophagus increases during systemic hypercapnia in anesthetized cat
Author(s) -
Held Heather E.,
Dean Jay B.,
Lindsey Bruce G.,
Pitts Teresa C.,
Rose Melanie J.,
Mortensen Ashley,
Nicholas Justine N.,
Baekey David M.,
Davenport Paul W.,
Bolser Donald C.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.894.21
Subject(s) - hypercapnia , stomach , esophagus , medicine , ventilation (architecture) , respiratory acidosis , anesthesia , acidosis , chemistry , mechanical engineering , engineering
The stomach extracts arterial CO 2 during respiratory acidosis to produce HCl & HCO 3 − , which react in the lumen to re‐form CO 2 . This study tested the hypothesis that hypercapnia stimulates gastric CO 2 removal via the esophagus. Tracheal and esophageal CO 2 (P EsCO2 ) and flows were measured in 13 anesthetized, pyloric occluded cats. Tracheal and gastric CO 2 output (V̇ GCO2 ) and gastric minute ventilation (V̇ G ) were calculated during tracheal air breathing for 30min (Control) and CO 2 breathing: 10%CO 2 in air (1hr), recovery in air (30min), followed by 6×10min alternating paired bouts of 10%CO 2 and air (10CO 2 , 10air). CO 2 breathing increased P EsCO2 above control 77% after 1hrCO 2 and 123% during 10CO 2 . Coughing revealed more CO 2 was present in the stomach: P EsCO2 increased 134% (in air) and 115% (after 1hrCO 2 ) compared to pre‐cough P EsCO2 . V̇ GCO2 ranged from 0–15% (X̄=2.5%) of total CO 2 output during 1hrCO 2 . V̇ G was 27% higher during 10CO 2 versus 10air. Relative to control, V̇ G increased 95% after 1 hrCO 2 and 148% after the first bout of 10minCO 2 . The results show a dynamic, supplemental CO 2 ‐eliminating response by the gastroesophageal system during systemic hypercapnia (NIH HL89104, HL103415 & ONR).