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Social defeat stress‐induced hyperthermia involves non‐shivering thermogenesis in brown adipose tissue
Author(s) -
Kataoka Naoya,
Nakamura Kazuhiro
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.891.14
Subject(s) - thermogenesis , brown adipose tissue , social defeat , hyperthermia , social stress , endocrinology , raphe , medicine , shivering , sympathetic nervous system , thermoregulation , biology , neuroscience , adipose tissue , serotonin , anesthesia , receptor , blood pressure , serotonergic
Psychological stress‐induced hyperthermia is a fundamental autonomic response in mammals. However, it is controversial whether this stress response involves sympathetic thermogenesis in brown adipose tissue (BAT). We have previously reported that systemic blockade of β 3 ‐adrenoreceptors, a major adrenoreceptor subtype in BAT, reduces hyperthermic response evoked by social defeat stress, a psychological stress model and that this stress activates medullary raphe sympathetic premotor neurons that are known to control BAT thermogenesis for cold defense and fever ( Eur. J. Neurosci. 34:1442–1452, 2011). To further examine the involvement of BAT thermogenesis in psychological stress‐induced hyperthermia, here, we directly measured changes in both interscapular BAT temperature and abdominal temperature of rats using a telemetry system. Rats that received social defeat stress exhibited an immediate increase in BAT temperature and also a delayed elevation of abdominal temperature. This result provides direct evidence that non‐shivering BAT thermogenesis contributes to hyperthermic response to social defeat stress, a model close to stress in human society.