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Neuropeptide Y is associated with changes in appetiteassociated nuclei but not food intake in a hypophagic avian model
Author(s) -
Newmyer Brandon Anthony,
Siegel Paul B.,
Cline Mark Andrew
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.889.12
Subject(s) - neuropeptide y receptor , orexigenic , endocrinology , medicine , hypothalamus , lateral hypothalamus , food intake , biology , neuropeptide , receptor
The central mechanisms through which neuropeptide Y (NPY) exerts its potent orexigenic effect as well as potential roles for NPY in central pathways governing eating disorders have been heavily investigated since its original isolation. However, to our knowledge NPY has not been studied concurrently in polygenic models of hypo‐ and hyperphagia. Thus, this study was designed to evaluate the hypothesis that NPY is associated with differential food intake responses in lines of chickens that have undergone long‐term genetic selection for low (LWS) or high (HWS) juvenile body weight and exhibit hypo‐ and hyperphagia, respectively. LWS chicks did not respond to any dose of NPY tested (59 pmol to 5.2 nmol), while HWS chicks responded to all doses of NPY at similar magnitudes throughout the duration of observation. To examine potential differences in brain chemistries between HWS and LWS chicks after NPY administration, neuronal activity in the hypothalamus was quantified using c‐Fos immunohistochemistry. Both lines responded with similar increases in c‐Fos immunoreactivity in the lateral hypothalamus and both divisions of the paraventricular nucleus; there were no significant line or line by treatment interactions. These results support that altered body weights may be related to differential NPY‐associated food intake pathways in these lines and may have implications in the development of pharmacological options to reverse eating disorders.