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Non‐invasive integrative analysis of cardiac energetics, translation to human heart in vivo
Author(s) -
Diolez Philippe Henri,
Deschodt-Arsac Veronique,
Chapolard Mathilde,
Hocini Meleze,
Jais Pierre,
Haissaguerre Michel
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.887.12
Subject(s) - human heart , cardiovascular physiology , cardiology , medicine , contraction (grammar) , heart disease
We propose MOCA, an inovative non‐invasive clinical analysis of heart energetics, based on the combination of non‐invasive MRS & MRI techniques and the analytical background of metabolic control analysis. MoCA brings new informations on the links between ATP demand and supply and delivers the description of heart function through integrated internal regulations, currently not accessible clinically. We anticipate that these informations may be of great help in the future for diagnosis and therapeutics follow‐up in human heart pathologies. By combining 31P‐NMR spectroscopy with direct measurement of heart contractile activity, we applied MoCA approach to beating Langendorf perfused rat heart and demonstrated the parallel activation of mitochondrial activity and myofibrils ATPases by Ca2+, which explains the energetic homeostasis of the heart. Further, we could describe quantitatively the global action of modulators of heart contraction (adrenaline, levosimendan) or of a pathology (hypoxia), and the relative importance of the different routes within the heart by which the effects are transmitted. Application to the study of contraction energetics in healthy and pathological heart in human may be a key to the understanding of the links between molecular events in pathologies and whole organ function/dysfunction.