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Estrogen protects against hypertension during autoimmune mediated hypertension
Author(s) -
Gilbert Emily L,
Venegas-Pont Marcia,
Mathis Keisa W,
Wasson Katie L,
Ryan Michael J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.880.3
Subject(s) - medicine , endocrinology , albuminuria , estrogen , inflammation , blood pressure , systemic lupus erythematosus , disease
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Because SLE predominantly affects young women, estrogen is commonly implicated in disease development. Hypertension, a major cardiovascular risk factor, is highly prevalent in women with SLE for reasons that are unclear. Based on the presumed role of estrogen to promote SLE and the prevalent hypertension, we hypothesized that estrogen promotes hypertension during SLE. To test this, 30‐week old female mice with SLE (NZBWF1) and controls (NZW/LacJ) were subjected to an ovariectomy (OVX) or sham operation. After 4 weeks of recovery, mean arterial pressure (MAP in mmHg) was measured by carotid catheters in conscious mice. MAP was higher in SLE sham mice compared to control sham mice (133±4 vs. 120±2, n=11, p<0.05). MAP was elevated further in SLE OVX mice (153±4, n=6, p<0.05 vs. SLE sham) but not in control OVX mice (118, n=2). Albuminuria (>100 mg/dL) developed in 27% of the SLE sham mice compared to 0% of sham or OVX control mice. 100% of SLE OVX mice developed albuminuria during this time. Renal expression of RORγ, a transcription factor specific for interleukin 17 producing T cells, is increased in OVX SLE mice compared to sham SLE mice. These data suggest that estrogens protect against, rather than promote, SLE hypertension and renal injury by suppressing renal inflammation. HL085907 , HL092284and HL085907S1 (MJR), andHL051971(UMMC‐Physiology) .