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Structural Biology of Methylation‐mediated Epigenetic Regulation
Author(s) -
Patel Dinshaw J.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.88.3
Subject(s) - epigenetics , dna methylation , atrx , cpg site , histone , methylation , biology , genetics , dna , computational biology , gene , gene expression , mutation
The lecture will present our research on recognition events controlling epigenetic regulation mediated by methylation marks on histone tails and at CpG sites on DNA. Specific topics will include recognition of methyllyisne marks by reader elements in ADD ATRX (Haitao Li), TRIM24/33 (Zhanxin Wang) and MLL1 (Zhanxin Wang and Jikui Song), erasure of lysine methylation marks by the KMD2A jumonji family lysine demethylases (Zhongjun Cheng), and DNMT1‐mediated active and autoinhibitory mechanisms of maintenance DNA methylation (Jikui Song). Collaborators: Yang Shi (Harvard) and Haitao Li (Tsinghua) on ADD ATRX , C. David Allis (Rockefeller) on MLL1, Michelle Barton (M. D. Anderson) on TRIM24, Joan Massague (Sloan‐Kettering) on TRIM33, and Or Gozani (UCSF) on KMD2A.