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Enhancer mediated regulation of developmental gene expression
Author(s) -
Wysocka Joanna K
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.88.2
Subject(s) - enhancer , chromatin , biology , enhancer rnas , histone , computational biology , transcription factor , embryonic stem cell , regulation of gene expression , epigenetics , microbiology and biotechnology , chia pet , genetics , epigenomics , gene , chromatin remodeling , gene expression , dna methylation
Cell‐fate transitions involve the integration of genomic information encoded by regulatory elements, such as enhancers, with cellular and signaling environments. Identification of genomic sequences that control human embryonic development represents a formidable challenge, as they are embedded within a vast non‐coding genomic space. However, enhancers share certain chromatin features, including presence of specific histone modifications and general coactivators. We have recently shown that unique chromatin signatures can be used to annotate two functionally distinct classes of enhancer elements in human embryonic stem cells (hESC): active and poised. We now extended enhancer profiling to other embryonic cell types. I will discuss our new findings on the dynamics of enhancer regulation during development and on transcription factors and chromatin modifiers involved in that process.