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Body weight (BW) and body fat (BF) gain due to ovarian hormone loss is attenuated by inhibiting angiotensin converting enzyme (ACE) or angiotensin type 1 receptors (AT1R) in Dahl salt‐sensitive (DS) female rats
Author(s) -
Ji Hong,
Zheng Wei,
Bajaj Bilkish,
Wu Xie,
Liu Jun,
Sandberg Kathryn
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.877.14
Subject(s) - endocrinology , medicine , ovariectomized rat , chemistry , losartan , angiotensin ii , angiotensin converting enzyme , captopril , adipose tissue , weight gain , receptor , hormone , body weight , blood pressure
Objective Ovarian hormone loss increases BW and BF gain in women. We and others have shown that ovariectomy (Ovx) increases BW while 17β‐estradiol replacement prevents this effect in DS rats and other animal models. Previous studies implicate the renin angiotensin system (RAS) in BF regulation. Here, we studied the effect of captopril (C), an ACE inhibitor and losartan (L), an AT 1 R antagonist (0.5g/L each, drinking water) on BW and BF gain induced by Ovx. Method Female DS rats were sham‐operated (Sh; n=6) or ovariectomized and treated with vehicle (Ovx), C (Ovx+C) or L (Ovx+L) and maintained on a low sodium (0.01% Na + ) diet for 3 months. Results Analysis of lean and fat mass by DXA revealed that while Ovx had no effect on the % lean mass gain, Ovx increased the accumulation of BF (p<0.01 vs Sh) and BW (p<0.0001 vs Sh), while both C & L attenuated these effects [BF (% increase from Sh): Ovx, 139; *Ovx+C, 113; *Ovx+L, 115; *p<0.05 vs Ovx; BW (final‐initial)gm/day: Ovx, 0.40; *Ovx+C, 0.27; *Ovx+L, 0.22; *p<0.01 vs Ovx]. The glucose dysregulation induced by Ovx was also markedly improved by C or L treatment. Conclusions These findings suggest that 17β‐estradiol loss causes dysregulation of the adipose RAS and thereby contributes to Ovxinduced BF and BW gain and glucose insensitivity. Supported by AG19291 & HL57502.