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Caffeic acid and ferulic acid improves diet induced metabolic syndrome in mice
Author(s) -
Costa Bocco Barbara Miranda Leite,
Lorena Fernanda Beraldo,
Fernandes Gustavo Werpel,
Cysneiros Roberta Monterazzo,
Ribeiro Miriam Oliveira
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.877.11
Subject(s) - ferulic acid , caffeic acid , metabolic syndrome , chemistry , endocrinology , antioxidant , medicine , obesity , biochemistry
The use of plants for medicinal benefits has been widely explored. Analysis of chloroform extract of Baccharis articulate indicated the presence of fenolic compounds as caffeic acid (CA) and ferulic acid (FA) that act as an antioxidant and anti‐inflammatory and anti‐diabetic, among others. The aim of this study was to analyze the effect of CA and FA on the metabolic syndrome. To this end, C57 mice were treated for 60 days with high fat diet (HFD) (40%) to induce the metabolic syndrome and concomitantly with CA plus FA. Our results showed that the combination of CA (0.9 mg / kg / day) and FA (25 or 50 mg/kg/day) reduced body weight gain induced by HFD (9.3±3.7 HFD; 3.7±0.7 (CA0,9+FA25) and 3.5±0.7 (CA0.9+FA50); p<0.001), fasting hyperglycemia (258±39 HFD, 208±28 (CA0.9+FA25); p<0,05 and 94±14 (CA0.9+FA50); p<0.001), but not hypercholesterolemia (100 ±14 HFD vs. 128±14 (CA0.9+FA25) and 104±7 (CA0.9+FA50)) induced by high fat diet. Surprisingly, all the parameters worsen when treated with 1.8 mg/kg/day of CA. In conclusion, the combination of caffeic acid and ferulic acid improves the abnormalities observed in metabolic syndrome induced by high fat diet.