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EFFECT OF EXOGENOUSLY ADMINISTERED H2S ON THE CARDIAC AND RENAL FUNCTION IN HYPERTENSIVE DIABETIC RATS
Author(s) -
Rathore Hassaan Anwer,
Din Fiazud,
Abdullah Mohammad H,
Khan Ayaz A,
Zubaid Munavvar,
Abdullah Nor Azizan,
Johns Edward J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.876.7
Subject(s) - streptozotocin , medicine , endocrinology , blood pressure , diabetes mellitus , spontaneously hypertensive rat , mean arterial pressure , renal function , xylazine , renovascular hypertension , heart rate , ketamine , anesthesia
This study investigated the action of exogenously administered H2S on mean arterial pressure (MAP), heart rate (HR) and renal function in combined states of hypertension and diabetes. Groups (n=6) of spontaneously hypertensive rats (SHR) or DOCA salt hypertensive (DOCA) rats received vehicle, streptozotocin (STZ) or STZ plus Sodium Hydrogen Sulphide (NaHS), at 56μmol/Kg i.p daily for 35 days; theerafter, MAP, HR and GFR were measured in Ketamine + Xylazine anaesthetized rats. Data, mean±SEM, were subjected to ANOVA and significance set at p<0.05. MAP of SHR‐STZ was higher than DOCA‐STZ (145±2 vs 155±2) (p<0.05) whereas it was similar in the SHR‐STZ‐NaHS (132±3 mmHg) and DOCA‐STZ‐NaHS groups. HR of SHR‐STZ at 343±5 b/minwas higher than DOCA‐STZ 314±7b/min (p<0.05) but was similar (312±19b/min) in SHR‐STZ‐NaHS vs DOCA‐STZ‐NaHS. GFR of DOCA‐STZ was lower than SHR‐STZ (0.5±0.03 vs 1.1±0.1ml/min/100g) whereas SHR‐STZ‐NaHS was 66% higher than that of DOCA‐STZ‐NaHS (p<0.05). Improved cardiovascular function with NaHS was likely due to decreased HR and reduced renovascular resistance through vasodilation in both DOCA and SHR concomitant with the development of diabetes.