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Role of the sympathetic nervous system in mediating hypertension in a model of polycystic ovary syndrome in rats.
Author(s) -
Lima Roberta,
Mara Rodrigo,
Reckelhoff Jane F
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.875.14
Subject(s) - polycystic ovary , medicine , endocrinology , denervation , heart rate , sympathetic nervous system , blood pressure , cardiology , obesity , insulin resistance
Hypertension (HT) is one of the major risk factors for cardiovascular disease in women with polycystic ovary syndrome (PCOS). Dysregulation of sympathetic nervous system (SNS) has been proposed to contribute to etiology of HT in women with PCOS. This study tested the hypothesis that activation of the SNS plays an important role in mediating HT in PCOS. We used hyperandrogenomic female (HAF) rat model in which dihydrotestosterone (DHT) (7.5 mg/90 days or placebo (PL)) pellets were implanted subcutaneously in female SD rats at 4 weeks of age and compared to PL. At 8wks age placebo and HAF rats underwent uninephrectomy, after two weeks, underwent unilateral kidney denervation (RD) or sham (SH) surgery and telemetry transmitter implantation. After two weeks recovery (12wks of age, 8wks DHT or PL), mean arterial pressure (MAP) and heart rate (HR) were recorded for 5 days. RD significantly decreased BP in HAF rats compared to SH (104±2mmHg,n=4vs115±3mmHg,n=5;p<0.05), but had no effect on MAP in PL group compared to SH (100±2mmHg vs104±1mmHg, n=5; p>0.05). HR was also not different between PL‐SH compared to RD (398±4mmHg, vs 411±4mmHg, n=5; p>0,05) and HAF‐SH compared to RD (366±10mmHg, n=5 vs 366±6mmHg, n=4; p>0,05). These data indicate that the renal nerves play a key role in the control of MAP in HAF rats, and suggest that elevated MAP in women with PCOS could be treated with SNS blockers. Supported by NIH HL66072, HL69194, HL51971.