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The adenosine system in skeletal muscle of individuals with essential hypertension and the effect of physical training
Author(s) -
Jensen Lasse Gliemann,
Nyberg Michael,
Thaning Pia,
Hellsten Ylva,
Mortensen Stefan Peter
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.872.12
Subject(s) - medicine , vasodilation , essential hypertension , prostacyclin , skeletal muscle , adenosine , aerobic exercise , hemodynamics , endocrinology , cardiology , blood pressure
The study examined vascular function and the adenosine (ADO) system in skeletal muscle of individuals diagnosed with essential hypertension (EH; N=10) and normotensive (N; N=11) individuals, before and after a period of aerobic training. Before and after the training period, the subjects participated in two experiments in which a) leg blood flow was determined during arterial infusion of ADO, acetylcholine (ACh) or during exercise, and b) interstitial fluid was sampled from v. lateralis muscle during exercise and ADO infusion. Leg vascular conductance (LVC) in response to arterial ADO infusion was similar in the EH and N group. Interstitial ADO formation during exercise was lower in the EH than the N group. In EH, the period of training did not affect vasodilator responsiveness to arterially infused ADO but improved the formation of interstitial ADO and prostacyclin. In the N group, training resulted in a lower LVC in response to arterial ADO infusion, which was paralleled by a lower leg blood flow during submaximal exercise. In conclusion, whereas the responsiveness to circulating ADO in individuals with essential hypertension remained unaltered with training, the capacity to form ADO and prostacyclin at the microcirculatory level was enhanced, suggesting an improvement in microvascular blood flow regulation. In normotensive individuals, aerobic training reduced the vasodilatory response to intraluminal ADO.