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Exercise training alters postprandial serum RBP4 in older adults
Author(s) -
Brandauer Josef,
Weiss Edward Paul,
Berardinelli Danielle Marie,
Hagberg James Michael
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.869.10
Subject(s) - postprandial , medicine , ingestion , meal , endurance training , endocrinology , area under the curve , adipokine , insulin , insulin resistance
Serum retinol binding protein 4 (sRBP4) is a specific carrier for retinol and an adipokine that has been associated with insulin resistance. The purpose of this study was to determine the effect of six months of endurance training on fasting and postprandial sRBP4 concentrations in response to ingestion of a high‐fat, high‐calorie meal. Sedentary 50‐ to 75‐year‐old men and women (n=11) underwent endurance training (≈70% VO 2 max, 20–40 min/session, 3–4 times/week). Serum samples were obtained after an overnight fast and periodically for 4 hours after the ingestion of a high‐fat meal. Serum RBP4 was assayed via immunoblotting. Fasting sRBP4 levels remained unchanged following endurance training (1.00±0.107 (mean±S.E.M) arbitrary units [AU] vs. 0.99±0.138 AU; p=0.93). A postprandial sRBP4 peak was observed at 60‐min, which was absent in the trained state (sedentary, +0.19 ±0.097 AU; trained, −0.10 ± 0.049 AU, p=0.01). Training had a prolonged effect on postprandial sRBP4 as assessed via incremental area under the curve (AUC) calculations (sedentary, 17.5±11.87 AU·180 min −1 , trained, −9.7±5.07 AU·180 min −1 ; p=0.03). In conclusion, fasting sRBP4 remained unchanged after six months of endurance training. The postprandial serum RBP4 increase observed in sedentary individuals was attenuated following exercise training.