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Assessing the contribution of distinct vascular segments in arterial insufficiency
Author(s) -
Arciero Julia,
DiStasi Matthew,
Unthank Joseph
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.860.9
Subject(s) - medicine , arteriogenesis , perfusion , femoral artery , collateral circulation , microcirculation , arterial insufficiency , vascular occlusion , anatomy , occlusion , artery , hindlimb , cardiology , arteriole , ischemia
Clinical studies indicate that vascular adaptations following an acute major arterial occlusion are capable of completely restoring resting perfusion. Similar responses are reported in animals, but the specific role of collaterals and the distal microcirculation remains controversial. In this study, a mathematical model was developed to predict how changes in the diameters of collateral and microvascular segments would contribute to compensation after focal femoral artery occlusion. The model was based upon proximal and distal pressures as well as dimensions of the femoral, saphenous, profunda femoral, and gracilis arteries in mouse hindlimb, and future studies will include microvascular dimensions in adductor and gastrocnemius muscles. The model confirms experimental observations that arterial occlusion shifts the site of primary vascular resistance from arterioles to small arteries which form collateral pathways. The model also predicts that a 60% increase in collateral artery diameter could explain the perfusion data even if distal vessel diameters were reduced as much as 22% due to reduced pressure.