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The effects of caffeine on vascular injury‐induced neointimal hyperplasia
Author(s) -
White Ryan Dean,
Chang Yingzi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.841.6
Subject(s) - neointimal hyperplasia , restenosis , neointima , medicine , caffeine , hyperplasia , inflammation , vascular smooth muscle , angioplasty , balloon catheter , endocrinology , cardiology , urology , balloon , stent , smooth muscle
Vascular restenosis after angioplasty is a major hindrance to the lasting success of surgical revascularization as a treatment of myocardial infarction. Chronic inflammation stimulates vascular smooth muscle cell migration and proliferation leading to neointimal hyperplasia. It is reported that chronic caffeine use suppresses inflammation by upregulating adenosine receptors. Our current study was designed to test the hypothesis that caffeine decreases vascular injury‐induced neointimal hyperplasia by suppressing inflammation. Male Sprague‐Dawley rats were fed 10 mg/kg caffeine, 20 mg/kg caffeine, or vehicle for two weeks followed by balloon catheter‐induced carotid artery injury. Rats were sacrificed after two weeks of continued treatment. Carotid arteries were collected and neointimal formation was compared. Rats that received caffeine showed a significant reduction of intima thickening (P<0.001) and neointima to media ratio (P<0.05) when compared to control rats. No significant differences were found between 10 mg/kg and 20 mg/kg caffeine treatment groups. Our results indicate that chronic caffeine use decreases vascular injury‐induced neointimal hyperplasia. Research support provided by the ATSU Graduate Program.