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Evidence for a limbic cortical HPA‐inhibitory network and its role in chronic stress‐induced HPA axis hyperactivity
Author(s) -
Radley Jason
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.84.2
Subject(s) - stria terminalis , neuroscience , forebrain , amygdala , limbic system , prefrontal cortex , inhibitory postsynaptic potential , hypothalamus , extended amygdala , chronic stress , psychology , hippocampus , pyramidal cell , septal nuclei , central nervous system , cognition
A network of interconnected cell groups in the limbic forebrain regulates hypothalamic‐pituitary‐adrenal (HPA) activation during emotionally stressful experiences, and disruption of these systems is broadly implicated in stress‐related psychiatric and systemic illnesses. A significant challenge to progress has involved unraveling the circuitry and mechanisms providing for regulation of HPA output, as these limbic forebrain regions do provide any direct innervation of HPA effector cell groups in the paraventricular hypothalamus. While the current view involves a layer of cell groups providing an array multisynaptic parallel pathways between the limbic forebrain and PVH, recent advances in our research will highlight evidence for a discrete region within the bed nucleus of the stria terminalis that serves as a neural hub for receiving and integrating these influences. Insights gleaned from clarifying the mechanisms of HPA control during acute emotional stress have provided a framework for ongoing studies examining the relationship between chronic stress‐induced plasticity in key cell groups (notably, the medial prefrontal cortex) and HPA axis hyperactivity.