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Changes In The Expression Of Phosphate Transporters, Inflammatory Markers, and Bone Cytokines With Increasing Age
Author(s) -
Loayza Marco S.,
Shum Laura,
Ferguson Virgina,
Levi Moshe,
King Karen
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.835.21
Subject(s) - diabetes mellitus , endocrinology , skeleton (computer programming) , transporter , medicine , bone remodeling , kidney disease , homeostasis , osteoporosis , population , biology , physiology , biochemistry , gene , anatomy , environmental health
Aging is a complex biological process with many factors 1 . Regulation of a single ion such as phosphorus (P i ) can change with age. P i takes part in cell signaling, energy metabolism and nucleic acid synthesis 2 . It is systemically regulated by the intestine and kidney 3 . P i regulation declines with age 3 and in diseases like diabetes mellitus and chronic renal disease. Disruption of P i regulation can lead to disease in skeletal and cardiac systems, as well as further renal issues 4 . Since 85% of P i is stored in the skeleton 5 , we focused on aging bone where the effects of systemic P i dysfunction are apparent 3 . Mice aged 12, 80, and more than 100 weeks were euthanized. Femurs were harvested for gene expression analysis of P i transporters, cytokines, and inflammatory markers. Fold‐changes in expression were determined using 2 −ΔΔCτ method. The difference between age groups was analyzed using one way ANOVA. The results show that P i homeostasis is not efficient with older age. Expression of P i transporters and bone health markers both change with age. Understanding the link between chronic diseases and bone health is vital to the aging population for future management and prevention.