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Gut microbiota modulates metabolic and nutrient sensing signaling pathways in obesity
Author(s) -
Duca Frank,
Sakar Yassine,
Covasa Mihai
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.830.5
Subject(s) - gut flora , nutrient sensing , lipogenesis , biology , obesity , adipogenesis , phenotype , signal transduction , endocrinology , nutrient , receptor , microbiology and biotechnology , medicine , lipid metabolism , adipose tissue , immunology , biochemistry , ecology , gene
Accumulating evidence shows a complex interaction between gut microbiota, weight gain and energy regulation. However, the mechanisms by which this interaction occurs to influence satiety and food intake leading to body weight changes in animals prone for obesity (OP) are not well known. Therefore, in these studies, we first examined changes in lipogenic and adipogenic markers, as well as intestinal nutrient signaling components (GPCRs) in OP and obese‐resistant (OR) rats. Next, we examined whether the metabolic and intestinal “phenotypical signatures” present in OP and OR rats are transferable, by inoculating germ free animals with fecal microbiota obtained from OP (OP/GF) and OR (OR/GF) donor rats. After 8wks of high‐fat feeding, we found that OP/GF animals gained more weight, and had increased adiposity and 24hr food intake compared to OR/GF. Alterations in lipogenesis and adipogenesis, as well as intestinal nutrient receptor signaling molecules characteristic of the OP phenotype were recapitulated in the germ free animals that received microbiota from the OP rat. These results demonstrate the ability of the gut microbiota to modulate host metabolism, by altering both intestinal nutrient sensing and energy‐storing signaling pathway information, and ultimately contributing to the obese state. Grant Funding Source : INRA