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Diverse Effects of a Low Dose Supplement of Lipidated Curcumin in Healthy Middle Aged People
Author(s) -
DiSilvestro Robert A,
Joseph Elizabeth,
Bomser Joshua
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.823.30
Subject(s) - curcumin , chemistry , absorption (acoustics) , catalase , pharmacology , antioxidant , biochemistry , medicine , physics , acoustics
Curcumin extracts of turmeric are proposed to produce health benefits. However, such supplements often show poor absorption and have generally been tested just in people with existing health problems. In a new study, healthy middle aged men and women were given a low dose (80 mg) of curcumin in a form expected to have good absorption (LONGVIDA®, a mix of curcumin +stearic acid+lecithin+other ingredients). Curcumin (N=19), but not placebo (N=19), had diverse effects: lowered plasma triglyceride values, lowered salivary amylase levels, raised salivary radical scavenging capacities, raised plasma catalase activities, lowered plasma beta amyloid protein concentrations, lowered plasma sICAM readings, increased plasma myeloperoxidase without increased c‐reactive protein, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities. Collectively, these results show that a low dose of a curcumin can produce a variety of potentially health promoting effects in healthy middle aged people. Although the study did not measure curcumin absorption directly, the effects on multiple body measures suggests efficient absorption. The work was supported by Verdure Sciences.