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Hepatoprotective effects of Rubus coreanus Miquel concentrates on liver injuries induced by carbon tetrachloride in rats
Author(s) -
Chyun Jong-Hee,
Chae Hyun-Jung,
Yim Jung-Eun
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.823.29
Subject(s) - tbars , carbon tetrachloride , liver injury , alkaline phosphatase , chemistry , transaminase , alanine transaminase , lipid peroxide , medicine , traditional medicine , endocrinology , biochemistry , lipid peroxidation , antioxidant , enzyme , organic chemistry
As well‐being foods pursuing healthy life are getting popular, and interests for Rubus coreanus Miquel (RCM) fruit, kind of Korean blackberry, are heightening as its medical actions, which are protecting liver, brightening eyes, and in curing diabetes, are known. This study was carried out to evaluate hepatoprotective effects of RCM concentrates on liver injuries induced by carbon tetrachloride (CCl 4 ) in rats. RCM, produced in June~July 2008 at Chunbook, Gochang, mashed fine. The seeds of RCM were removed and the juices were condensed. 32 Sprague‐Dawley rats were divided into normal group, CCl 4 group (8 rats), 1% RCM group, and 2% RCM group. Experimental diets were provided to experimental animals for four weeks. We measure blood total cholesterol, HDL‐cholesterol, Glutamic oxaloacetic transaminase (GOT), Glutamic pyruvic transaminase (GPT), and Alkaline phosphatase (ALP). Part of the livers was separated for hitopathological observation, and measured lipid peroxide (TBARS) and liver protein. The activities of serum GOT, GPT and ALP were elevated by CCl 4 administration and levels of hepatic TBARS were also significantly increased in CCl 4 groups. However, the hepatic TBARS levels and activities of serum enzymes were markedly reduced by supplementation of the RCM concentrates (p<0.05). In histopathological observation, massive necrosis in centrilobular area and degenerative changes by CCl 4 were recovered by dietary supplementation of RCM concentrates. These findings indicate that RCM concentrates have hepatoprotective effects and may improve symptoms of liver injuries.