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Effects of protein quantity and source (animal versus plant) on indices of mood and fed‐state large neutral amino acids and tryptophan profile
Author(s) -
Hogan Jacqueline Anne,
Armstrong Cheryl LH,
Wilson Hailey Kay,
Campbell Wayne W
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.820.26
Subject(s) - tryptophan , profile of mood states , mood , chemistry , meal , zoology , endocrinology , overweight , medicine , food science , amino acid , obesity , psychology , biochemistry , biology , psychiatry
The balance between plasma tryptophan (Trp) and other large neutral amino acids (LNAA) from dietary protein (P) influences serotonin synthesis which may impact indices of mood. This study was designed to assess effects of P quantity and source on fed‐state (FS) LNAA and Trp and mood. 34 overweight/obese adults (53±12 y, BMI 30.8±2.6 kg/m 2 , mean±SD) were randomly assigned to consume diets with 750 kcal/d below energy need and 10, 20 or 30% energy from P with beef/pork (5M:12F) or soy/pulses (6M:11F) as the predominate P source for 3 randomized 28d trials. On day 28, subjects consumed a trial‐specific test meal and completed the Profile of Mood Survey (POMS) before and 25, 60, 120, 180 and 240 min after eating. Fasting and FS LNAA and Trp were measured in 5 subjects each from the two P source groups. FS LNAA (weighted averages) was higher for beef/pork vs soy/pulses ( p <0.05), and progressively higher with increasing P intake ( p <0.01). Independent of source, FS Trp was greater ( p <0.01) and Trp:LNAA was lower ( p <0.05), for 30 vs. 20 and 10% P. Protein quantity and source did not affect total mood disturbance or the six POMS subcategories (vigor, fatigue, depression, confusion, tension, anger). While protein intakes predominately from meat or plant sources that span the acceptable macronutrient distribution range affect plasma LNAA and Trp, they do not acutely impact mood. Support: The Beef Checkoff, National Pork Board, NIH RR025761Grant Funding Source : The Beef Checkoff, National Pork Board, NIH RR025761