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Impact of a Combination of Various Functional Food Ingredients as TAI slim ® Total Body System, Weight Management Program: Randomized, Placebo‐controlled, Double‐blind Human Clinical Studies
Author(s) -
Amagase Harunobu,
Handel Richard
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.820.1
Subject(s) - placebo , postprandial , waist , medicine , appetite , weight loss , randomized controlled trial , placebo controlled study , meal , endocrinology , obesity , double blind , alternative medicine , pathology , insulin
We hypothesized that negative energy balance by a systematic procedure (TAI slim ® System) with increasing metabolic rate through physical activity and use of dietary supplement, TAI slim (containing indigestible dietary fiber, L‐phenylalanine, N‐acetyl‐L‐tyrosine, tea extract and Lycium barbarum ) b.i.d., and decreasing caloric intake by consuming fiber‐containing meal replacement (TAI slim SHAKE) b.i.d. and chew (TAI slim SKINNY) t.i.d. would be successful to lose weight in obese humans. Randomized, double‐blind, placebo‐controlled human clinical studies have shown that TAI slim System significantly reduced body weight by 9.2±0.8 (SEM)% compared to pre‐intervention or placebo group (1.1±0.6%) in 2 months. Other metabolic syndrome markers, such as waist circumference, total body fat, blood pressure, and fasting blood glucose level, were also significantly reduced by TAI slim System in a range of 5.8–10% compared to pre‐intervention or placebo (−0.2–1.9%). Postprandial Energy Expenditure was significantly increased by TAI slim System compared to placebo and baseline levels for more than 4 h post‐intake. TAI slim System also significantly suppressed appetite, measured by subjective visual analogue scale, by 39% compared to the baseline (11% reduction in the placebo). These results suggest that negative energy balance caused by the TAI slim System may be an effective body weight management procedure.