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Measurement of Body Fat Does Not Predict Cardiovascular Risk Factors in Metabolic Syndrome
Author(s) -
Kalil Graziela,
Sinkey Christine,
Haynes William
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.6
Subject(s) - waist , medicine , metabolic syndrome , body mass index , circumference , plethysmograph , body adiposity index , endocrinology , skin fold , cohort , body fat percentage , obesity , cardiology , classification of obesity , fat mass , geometry , mathematics
Background We hypothesized that measurement of body fat would predict cardiovascular risk factors. Methods In a prospectively recruited cohort of 30 middle‐aged obese subjects with metabolic syndrome (55±9 yr; 28% male; BMI 38±4; mean±SD) we assessed the association of risk factors with BMI, waist circumference and body fat content (by air displacement plethysmography, skin fold thickness, and Body Adiposity Index (hip/(height1.5))‐18)) using regression analysis. Results Waist (118±11 cm) and body fat (plethysmography: 48±7%; skin fold: 41±4%; BAI: 41±8%) were elevated. Waist circumference was a significant and strong predictor of fasting glucose (100±10 mg/dl; R=0.499; P=0.008) and HDL‐cholesterol (57±14 mg/dl; R=0.537; P=0.003). BMI significantly predicted hsCRP (5.4±6.4 mg/dl; R=0.387; P=0.04), and weakly predicted systolic BP (129±15 mmHg; R=0.339; P=0.08). Importantly, body fat content (whether by air displacement plethysmography, skin fold thickness or BAI) did NOT associate with cardiovascular risk factors. Conclusion In obese subjects with metabolic syndrome, measurement of body fat content does NOT associate with BP, lipids, glucose or inflammation. Waist circumference and BMI are better predictors of cardiovascular risk factors. Grant Funding Source : NHLBI