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Anti‐obesity Effect of microalgal oil Supplementation in C57BL/6N Mice Fed a High Fat Diet
Author(s) -
Lee Seon Hwa,
Choi Joohee,
Mun Eun-Gyung,
Cha Youn-Soo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.53
Subject(s) - fish oil , corn oil , polyunsaturated fatty acid , obesity , food science , lipid metabolism , soybean oil , biology , zoology , endocrinology , chemistry , medicine , fatty acid , biochemistry , fish <actinopterygii> , fishery
This study investigated the antiobesity effects of microalgal oil in C57BL/6J mice with diet‐induced obesity (DIO). Sixty male C57BL/6N mice aged 4 weeks were divided into 6 groups; ND (normal diet control), HD (high fat diet control 60% fat kcal), BT (high fat diet & beef tallow, 5g/kg), CO (high fat diet & corn oil, 5g/kg), FO (high fat diet & fish oil, 5g/kg), and MO (high fat diet & microalgal oil, 5g/kg). Mice in the DIO group were fed a high fat diet to induce obesity. The experiment was carried out for 12 weeks including diet program. The FO and MO groups have significantly decreased body weight gain, epididymal fat pad weights and serum TG, TC levels compared to the HD group and BT group. These results were supported by real time PCR analysis for mRNA expression of genes (ACO, CPT‐I, PPAR‐γ, SREBP‐1, FAS, SCD‐1) related to lipid metabolism. These results indicate that microalgal polyunsaturated oil might have an antiobesity effect on high fat diet‐ induced obese mice. All in all, n‐3 PUFA‐rich oil from microalgae is as good as fish oil regarding chemoprevention in diet induced obesity mice (This work was supported from Korea research institute of Bioscience & Biotechnology, open innovation project).