Premium
The association between Serum Estrogen, Fat Mass and Type II Diabetes in the Boston Puerto Rican Health Study (BPRHS)
Author(s) -
Landry Latrice,
Tucker Katherine
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.5
Subject(s) - type 2 diabetes , logistic regression , medicine , endocrinology , estrogen , diabetes mellitus , demography , obesity , gerontology , sociology
Background Research suggests that estrogen modulates adiposity and may be protective against diabetes (T2D). Data on the association between estrogen, obesity and diabetes is limited in Puerto Ricans. This study examines the cross‐sectional relationships between serum estradiol (E2) with gynoid and android fat mass and T2D in Puerto Rican adults in the Boston Puerto Rican Health Study (BPRHS). Design E2 and android and gynoid fat mass (from DXA) were measured in 538 BPRHS participants. Multivariate regression was used to assess cross sectional relationships between E2 and gynoid and android fat mass. Logistic regression was used to assess the associations with T2D. E2 and total energy intake were log transformed. Covariates included age, sex, pack years, physical activity score, menopausal status, hormone use, and intakes of total energy, fat, and carbohydrate. Results E2 was positively associated with gynoid (p<0.0001) and android (p<0.0001) fat and T2D (0.03). Android fat (p<0.0001) was positively associated with T2D. Gynoid fat (p<0.0001) was negatively associated with T2D. Conclusion Consistent with findings from other populations, our findings suggest a positive association between E2 and body fat and T2D. The inverse association between gynoid fat and T2D is novel. Longitudinal studies with adjustment for other metabolic measures are needed to clarify these potential associations. Grant Funding Source : NIH‐P01 AG023394 , Pfizer SNMA David E Satcher Fellowship