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Deletion of adipogenin gene in mice is effected to adipogenesis and deferred to growth
Author(s) -
KYOUNG-HA SO,
Tachizaki Taisei,
Aridiyanti Astrid,
Suzuki Yutaka,
Song Sang-Houn,
Roh Sang-gun,
Katoh Kazuo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.49
Subject(s) - adipogenesis , adipose tissue , adipocyte , leptin , medicine , endocrinology , biology , in vivo , obesity , genetics
Adipogenin, an adipocyte‐specific membrane protein highly expressed in adipose tissues of mice and cattle. However, the functional role of adipogenin in metabolic processes in vivo still unknown. The aim of this study was to demonstrate the effects of adipogenesis mechanism in adipogenin null mice (ADIG KO) on normal‐fat and high‐fat fed. Compared to control mice, ADIG KO male and female mice were not significantly increase in body weight both normal‐ and high‐fat diet fed. ADIG KO mice revealed lower fat composition than control mice in body, and comparable adipocyte size confirmed to smaller than control mice. Adipogenic genes such as PPAR‐γ2 and leptin were down‐regulated in adipose tissues of ADIG KO mice. These results indicate that adipogenin null mice showed the retard of the growth and fat accumulation that adipogenin refer to adipogenesis on adipose differentiation.