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Hypoglycemic Effect of Saururus chinensis Baill in ob/ob Mice
Author(s) -
Kim Jung-In,
Jeong Soo-Mi,
Kim Minju,
Kang Min-Jung
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.47
Subject(s) - glycated hemoglobin , insulin resistance , traditional medicine , medicine , christian ministry , insulin , endocrinology , chemistry , diabetes mellitus , type 2 diabetes , philosophy , theology
Saururus chinensis Baill was reported to have strong alpha glucosidase inhibitory activity in vitro and in vivo. The purpose of this study was to investigate the hypoglycemic effect of S. chinensis Baill in obese diabetic ob/ob mice. Four‐week‐old male ob/ob mice (n=16) were fed AIN‐93G diet or diet containing a 0.3% ethanol extract of S. chinensis Baill for 10 weeks after 1 week of adaptation. Blood glycated hemoglobin and serum glucose and insulin levels were measured and HOMA‐IR (Homeostasis Model Assessment‐Insulin Resistance) was calculated. Body weight, food intake, and serum insulin levels of the S. chinensis Baill group were not significantly different from those of the control groups. Consumption of S. chinensis Baill significantly decreased blood glycated hemoglobin, serum glucose, and HOMA‐IR compared with the control group (p<0.05). These results indicate that S. chinensis Baill is effective in improving insulin sensitivity and hyperglycemia in ob/ob mice. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009‐0090780).