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HPMC supplementation reduces weight gain, intestinal permeability, inflammation, and insulin resistance in dietinduced obese mice
Author(s) -
Kim Hyunsook,
Bartley Glenn,
Young Scott A.,
Yokoyama Wallace
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.819.46
Subject(s) - insulin resistance , endocrinology , medicine , adipose tissue , inflammation , insulin , weight gain , carbohydrate metabolism , immune system , lipid metabolism , intestinal permeability , diet induced obese , leptin , glucose uptake , chemistry , obesity , body weight , immunology
Consumption of diets high in soluble dietary fibers has been suggested to induce biomarkers for anti‐obesity and anti‐inflammation, and improve insulin resistance. To investigate the effects of hydroxypropyl methylcellulose (HPMC), a highly viscous soluble dietary fiber, on obesity‐induced metabolic complications, obese C57BL/6J mice were fed high fat diets with either 6 % HPMC or 6 % microcrystalline cellulose (MCC) for five weeks. Body weight gain and adipose tissue weight were significantly lower in HPMC fed mice compared with MCC. High‐fat diet induced intestinal permeability was lowered by HPMC. IPA analysis of exon microarray data from adipose tissue identified lipid metabolism and acute phase response pathways were regulated by HPMC. We confirmed that genes related to inflammation and immune response, and oxidative stress markers were down‐regulated by the HPMC diet. HPMC feeding markedly reduced area under the curve for 2‐hr insulin and glucose responses, indicating enhanced insulin sensitivity and glucose metabolism. These data suggest that consumption of HPMC ameliorates obesity‐induced insulin resistance via reduction of weight gain and anti‐inflammatory and immune response in adipose tissue as well as enhancing intestinal barrier function.