Premium
Obesity and premature gallstone disease: results from a cross‐sectional study of over 510,000 youths
Author(s) -
Koebnick Corinna,
Smith Ning,
Black Mary Helen,
Porter Amy H,
Richie Bradley A,
Hudson Sharon M,
Gililland Deborah Y,
Jacobsen Steven J,
Longstreth George F
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.816.5
Subject(s) - medicine , gallstones , overweight , obesity , odds ratio , cross sectional study , population , pediatrics , childhood obesity , obstetrics , environmental health , pathology
Objective To investigate the association between childhood and adolescent obesity and the risk of gallstones as a potential effect modification by oral contraceptive use in girls. Methods For this population‐based cross‐sectional study, measured weight and height, oral contraceptive use, and diagnosis of cholelithiasis were extracted from electronic medical records of 510,816 patients aged 10–19 years enrolled in an integrated health plan 2007–2009. Results We identified 766 patients with gallstones. The adjusted OR of gallstones for under/normal weight (=reference), overweight, moderate obesity, and extreme obesity in boys was 1.00, 1.46, 1.83, and 3.10 (95% CI 1.99–4.83) and in girls 1.00, 2.73, 5.75, and 7.71 (95% CI 6.13–9.71), respectively (P for interaction sex x weightclass <0.001). Among girls, oral contraceptive use was associated with higher odds for gallstones (OR 2.00, 95% CI 1.66–2.40). Girls who used oral contraceptives were at higher odds for gallstones than their counterparts in the same weight class who did not use oral contraceptives (P for interaction weight class x oral contraceptive use = 0.023). Conclusions Due to the shift towards extreme childhood obesity, especially in minority children, pediatricians can expect to face increasing numbers of children and adolescents affected by gallstone disease.