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Zinc and copper status are associated with bone mineral measures in lactating adolescent mothers
Author(s) -
Bezerra Flávia F.,
Maia Patricia A.,
Anastácio Alexandra,
Mendonça Laura M.C.,
Donangelo Carmen M.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.807.3
Subject(s) - zinc , bone mineral , copper , micronutrient , ceruloplasmin , medicine , food frequency questionnaire , lactation , zoology , endocrinology , bone mass , bone density , copper deficiency , metallothionein , chemistry , osteoporosis , biology , pregnancy , pathology , organic chemistry , genetics
We investigated the relationship between bone mass and copper and zinc status in lactating (LA, n=33, 8.7±3.4wk postpartum) and non‐lactating (NL, n=14) adolescents (14–19y). Total bone mineral content (TBMC), total (TBMD) and lumbar spine (L2‐L4, LSBMD) bone mineral density, dietary intake, copper (CuP), zinc (ZnP) and ceruloplasmin (Cp) in plasma, and zinc (ZnE) and metallothionein (MT‐E) in erythrocytes were assessed. Over 70% of adolescents in each group had zinc and copper intakes lower than RDA. Biochemical indices were similar between groups except for ZnE and MT‐E that were 26% and 123% higher, respectively, in LA than in NL ( P <0.05). LSBMD z score was lower in LA than in NL (−1.09 ± 1.5 vs. 0.04 ± 1.23, P <0.05). In LA, zinc intake was correlated with TBMC (r=0.38), TBMD z score (r=0.37) and LSBMD z score (r=0.37); ZnP was correlated with TBMC (r=0.44); and Cp with TBMD (r=0.50), LSBMD (r=0.42) and LSBMD z score (r=0.39) ( P <0.05). In NL, no significant correlations between bone mass indices and zinc or copper status were observed. Our results suggest that a poor copper and zinc nutritional status may exacerbate the magnitude of bone loss during lactation in adolescent mothers. Financial support: CNPq, FAPERJ (Brazil).