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Major Facilitator Superfamily Domain‐containing protein 2a is a novel regulator of hepatic lipid metabolism
Author(s) -
Berger Justin H,
Silver David L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.790.13
Subject(s) - major facilitator superfamily , regulator , microbiology and biotechnology , knockout mouse , ketone bodies , transporter , chemistry , flux (metallurgy) , metabolism , biology , receptor , biochemistry , gene , organic chemistry
Understanding how the body switches between storing and burning energy is a fundamental gap in our ability to better treat metabolic disease. The Major Facilitator Superfamily Domain‐containing protein 2a (MFSD2A) is a newly identified plasma membrane transporter that is nutritionally regulated in liver and brown adipose tissue. MFSD2A protein expression is not detectable in the livers of fed mice, but is highly induced during a fast in a PPARalpha‐ and glucagon receptor‐dependant manner. Additionally, MFSD2A turns over rapidly within 60 minutes, and disappears from the cell surface with similar kinetics. In order to investigate whether MFSD2A plays a role in lipid metabolism, we generated a conventional Mfsd2a knockout mouse model. In the absence of MFSD2A, normal triglyceride accumulation in the liver during a fast was not observed. Additionally, knockout mice exhibited increased energy expenditure and protection from diet‐induced weight gain, without changes to glucose homeostasis. Further data on the mechanism of MFSD2A will be presented. Taken together, our studies indicate that MFSD2A plays an important role in regulation of energy expenditure and liver triglyceride levels.